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He would not be able to implement his own agenda. He'd presumably still be signing the legislation a Democratic Congress does want to push through though? Assuming, of course, that the Senate totals wouldn't have changed as well. There were several close races. And if he'd chosen another senator as a running mate, that would be another -1. A divided Congress wouldn't be passing much of what Biden has signed into law either. And one has to wonder if McConnell would actually sit there and just leave vacancies on SCOTUS for a straight four years. If he did let the one through, you can be sure he'd never let a second go, not after the prospect of Roe being overturned was dangled.
Sanders isn't known for compromise. He'd opt for maximalist goals and end with nothing. Like his entire career in the Senate. There's no way we'd have an infrastructure bill. There's no way he'd give anything to Sinema or Manchin for their support. So it would really be 48-52, even assuming he didn't cost the Democrats seats in Georgia.