So tonal inconsistencies: the show couldn't seem to decide whether it was a dark and series drama, or classic martial arts show. The fight with the drunken master is one of the best examples of this, everything's dark and serious leading up to it, then the fight happens. It was a bit jarring, but that particular fight can be forgiven because it was so fun. I think the show would have been better off if it had leaned into it's martial arts film heritage, and did the whole thing like one of the old Jackie Chan films. They didn't need to try to be dark and gritty just to match the other Defenders, and it didn't really work well for this series.
The protagonist also had some inconsistent characterization. He started out as a naïve hippy, then turned into a idealistic man-child, and then just dropped the idealism. He worked best as a naïve hippy. The whole thing might have worked if there were some better character development, but there wasn't. If they wanted to go through with that characterization, I would have liked to see the idealism burned out of him a bit more. They had a good setup to do so with all the corporate shenanigans, but they passed on the opportunity and instead decide to treat Danny's simplistic view of the world as correct; they should have used the opportunity to show that things were a lot more complicated than he saw things, and that you can't just give away drugs and take responsibility for everyone who stops by with a sad story and expect things to work out right. They even seemed to be starting to go in this direction as the board pointed out that they already had plans in place to make sure that everyone who needed the drugs was going to get them, and that the factory being blamed for a few local incidents of cancer was in full compliance with the EPA and all the inspections turned up nothing wrong with it. They just needed to follow through and show the problems that Danny's meddling caused - losing funding for the development of new drugs for other diseases, a sudden influx of people trying to get some of those sweet sympathy settlements, maybe even finding an actual cause for the cancer cases somewhere else in the thousands of businesses on Staten Island, or even just pointing out that 15 cancer cases in a population of half a million isn't actually that unusual.
Finally, Claire seems to be a weirdness magnet. I'm glad they actually had Madame Gao point it out.