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  1. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    RB, My rather flippant response was because we're...

    RB, My rather flippant response was because we're clearly getting nowhere with this discussion. I have clearly articulated the sheer complexity of the decision involved here and my reasons for...
  2. I was actually surprised that people exited their...

    I was actually surprised that people exited their short positions given how awful the fundamentals are wrt the valuation. But then again I'm not willing to short other obviously overvalued stocks...
  3. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    Just curious - where did you learn immunology?...

    Just curious - where did you learn immunology? Because it must have been somewhere with much more sophisticated understanding and predictive power than where I was taught it.
  4. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    The only vaguely relevant information in that...

    The only vaguely relevant information in that link is the phase III results from Pfizer and AZN, which no one is disputing. Those data do not, however, represent comprehensive data on 'lower viral...
  5. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    You asked for my data for the range of efficacy I...

    You asked for my data for the range of efficacy I quoted; I referenced specific studies. I'm asking you for supposedly voluminous evidence of >50% reduction in viral load and hospitalizations after 1...
  6. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    Clalit (a major Israeli HMO) released...

    Clalit (a major Israeli HMO) released pre-publication data showing a 33% decrease in PCR positivity rate on days 14-18 post first dose, on about 200k patients matched against 200k who had not yet...
  7. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    He's speculating, I don't understand why you...

    He's speculating, I don't understand why you think this is some sort of slam dunk.


    No, we have data on weeks 3 and 4 that range from about 30% to about 90%, with the lower estimates consistently...
  8. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    RB, I can't emphasize enough how the evidence...

    RB, I can't emphasize enough how the evidence doesn't demonstrate that at all. We don't know how 1 dose vs. 2 doses will work because we haven't tested it. And the early data about efficacy in the...
  9. Replies
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    59

    Yes, because the US federal government is known...

    Yes, because the US federal government is known for its thriftiness. :p
  10. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    Flixy - I want to be clear, I wasn't critiquing...

    Flixy - I want to be clear, I wasn't critiquing you personally, I was more surprised that explicit guidance allowed people into other's homes, rather than having a recommendation of zero overlap,...
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    223

    Hmm. So I think it's a little bit of a stretch to...

    Hmm. So I think it's a little bit of a stretch to call it a holdover from royal prerogatives, nor was it included in the text of the Constitution willy-nilly (it's not an amendment, it's part of the...
  12. Replies
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    59

    I'm not sure why anyone cares one way or another?...

    I'm not sure why anyone cares one way or another? It's just a desk.

    To be honest I never really understood fine furniture or antiques. It always seems like way to much to pay for a table or desk...
  13. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    That's a pretty old sig, GGT. I think I added it...

    That's a pretty old sig, GGT. I think I added it while I was working on a team that had people trying to develop computational models for blood flow in complex situations (e.g. aortic regurgitation),...
  14. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    Huh, I'm not sure what the official guidance is...

    Huh, I'm not sure what the official guidance is in my state right now, but I don't think I've been in anyone else's home since March, nor has anyone outside of immediate family (and our summer nanny)...
  15. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    Wait a second, you're officially 'allowed' to...

    Wait a second, you're officially 'allowed' to have guests inside your home?
  16. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    The issue isn't the storage conditions...

    The issue isn't the storage conditions themselves, it's the differences in how each vaccine is handled, stored, dosed, etc. Making sure the right patient gets the right drug at the right time is...
  17. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    I spoke to my sister yesterday and she had some...

    I spoke to my sister yesterday and she had some thoughts that are relevant to recent discussions in this thread. For context, she runs a large hospital that is administered by the federal government...
  18. Thread: Singing

    by wiggin
    Replies
    5
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    199

    Hmm, I'm of two minds. If you've read Tolkien his...

    Hmm, I'm of two minds. If you've read Tolkien his books are full of interludes for songs, poems, chants, etc. He uses it to set the mood of a scene and at times it can be effective. When I first read...
  19. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    There is a difference between hoarding and...

    There is a difference between hoarding and planning. For a two dose regimen, you have to make sure you will be able to meet future demand based on expected supply; otherwise you risk compromising...
  20. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    Yes, the central government should not be using...

    Yes, the central government should not be using their last dose to give someone dose 1 if they aren't sure they'll be able to provide dose 2. They absolutely should have a reserve in place based on...
  21. Thread: covid-19

    by wiggin
    Replies
    2,577
    Views
    75,829

    This comes down to a failure of coordination by...

    This comes down to a failure of coordination by whoever is supplying the vaccines. If the central government provides clear guidance and commitments about when vaccines should be available and what...
  22. Replies
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    2,329

    An old bandmate of mine is now an NPR reporter in...

    An old bandmate of mine is now an NPR reporter in DC. She's posted some absolutely crazy stories and photos from Wednesday. People are pretty unmoored from reality.
    ...
  23. Replies
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    83,495

    All of these are reasons to value Tesla at higher...

    All of these are reasons to value Tesla at higher valuations than an established auto company. A valuation of $830 billion, however, is larger than the valuations of Toyota, Volkwagen, Daimler,...
  24. Replies
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    83,495

    I've been dumbfounded by Tesla's performance in...

    I've been dumbfounded by Tesla's performance in the last 6 months; frankly I just don't understand how the company could possibly be worth that much money, unless they somehow end up becoming the...
  25. Thread: teevee sucks

    by wiggin
    Replies
    1,572
    Views
    163,836

    My wife and I watched both seasons of I'm Sorry...

    My wife and I watched both seasons of I'm Sorry over the last week or two. It was pretty funny, I don't really know Andrea Savage at all, but she was pretty solid.

    Too bad they cancelled the third...
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