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Thread: What made you go WTF today?

  1. #3781
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    The metro station near my house is going to be renovated. That already is annoying all by itself, because they'll take forever to strip it, repaint it and put in a new elevator and they will simply shut down the entrance on my side for what I fear may be up to 6 months. Today the preparations started; on the parking space for bicycles which measures about 15 by 20 meters next to the entrance they had placed an announcement that they'd start removing bicycles as of the 7th of november, the start date of the work. Plates are about 60 by 100 cm and yellow with black lettering. So far so good, but the real WTF factor was that they put up 11 signs. It's like a bloody forest of notices.
    Congratulations America

  2. #3782
    They probably expect 10 to get stolen.
    Hope is the denial of reality

  3. #3783
    There are so many good charities asking for donations. Apparently, it costs about the same to adopt an orphaned/abused human child as it does for a cat or dog, around $16/month. WTF?

  4. #3784
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    Quote Originally Posted by Loki View Post
    They probably expect 10 to get stolen.
    By someone who wants to build a bicycle shed ?
    Congratulations America

  5. #3785
    Senior Member Flixy's Avatar
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    On the other hand, over here near the station, several bicycle stands had to be empty for construction, and they placed a 'normal' amount of signs, and there were a lot of bikes there after the deadline. I guess Amsterdam likes to make sure people can't claim they missed the signs
    Keep on keepin' the beat alive!

  6. #3786
    You guys can't manage to update your desktops, but you can make a gimmicky touch bar for your laptop? Wth?
    There's a man goin' 'round, takin' names
    And he decides who to free and who to blame

  7. #3787
    Can this election season be over already?

    Last edited by Loki; 10-28-2016 at 09:35 PM.
    Hope is the denial of reality

  8. #3788
    Your video got DMCA'd, Loki

  9. #3789
    Thanks. It's the Mike Kirk being a racist asshole video.
    Hope is the denial of reality

  10. #3790
    https://twitter.com/cblatts/status/792123583527055360

    Love the responses. Someone tries to be helpful and this is the price they pay. I swear some people care more about feigning outrage than actually helping people.
    Hope is the denial of reality

  11. #3791
    Quote Originally Posted by Loki View Post
    https://twitter.com/cblatts/status/792123583527055360

    Love the responses. Someone tries to be helpful and this is the price they pay. I swear some people care more about feigning outrage than actually helping people.
    That is pretty rich coming from you.

  12. #3792
    Have the offending tweets been deleted?
    "One day, we shall die. All the other days, we shall live."

  13. #3793
    It looks like most have been. 2 are still there though.
    Hope is the denial of reality

  14. #3794
    "One day, we shall die. All the other days, we shall live."

  15. #3795
    I'm impressed they knew what that meant.
    Hope is the denial of reality

  16. #3796
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    Quote Originally Posted by Loki View Post
    I'm impressed they knew what that meant.
    Oh well Ajax was treated to all sorts of jokes about the holocaust.
    Congratulations America

  17. #3797
    https://www.buzzfeed.com/tamerragrif...-paper-and-wro

    Assuming this is being accurately reported, what the hell is wrong with the professor?
    Hope is the denial of reality

  18. #3798
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    I was at the gym today. There was this young guy getting changed at the same time as I. I will admit he was quite a looker, but what really drew my attention was that his clothes changing routine (he was getting ready for his work-out) was very much an affair between him, his outfit and the mirror. I don't think I have never seen anyone look in a mirror that intently for that long ever before.
    Congratulations America

  19. #3799
    He was probably keeping an eye on you.
    "One day, we shall die. All the other days, we shall live."

  20. #3800
    http://www.theverge.com/2016/8/23/12...terstitial-ads

    Dear the entire Internet Marketing industry,

    WHERE IS YOUR GOD NOW, BITCHES
    When the sky above us fell
    We descended into hell
    Into kingdom come

  21. #3801
    Quote Originally Posted by Steely Glint View Post

    WHERE IS YOUR GOD NOW, BITCHES
    No gods

    No kings

    ONLY MAN
    In the future, the Berlin wall will be a mile high, and made of steel. You too will be made to crawl, to lick children's blood from jackboots. There will be no creativity, only productivity. Instead of love there will be fear and distrust, instead of surrender there will be submission. Contact will be replaced with isolation, and joy with shame. Hope will cease to exist as a concept. The Earth will be covered with steel and concrete. There will be an electronic policeman in every head. Your children will be born in chains, live only to serve, and die in anguish and ignorance.
    The universe we observe has precisely the properties we should expect if there is, at bottom, no design, no purpose, no evil, no good, nothing but blind, pitiless indifference.

  22. #3802
    I just learned that the first bioresorbable stent got CE Mark in Europe in 2011, based on nearly nonexistent clinical efficacy data. That's crazy - the FDA only gave the first approval this summer and based on the latest clinical data that just came out they are reconsidering the whole thing. I can't imagine how many thousands of patients have had substandard stents implanted in them because regulators were way too permissive. For that matter, I'm still confused why anyone thought current designs were a good idea in the first place.
    "When I meet God, I am going to ask him two questions: Why relativity? And why turbulence? I really believe he will have an answer for the first." - Werner Heisenberg (maybe)

  23. #3803
    Senior Member Flixy's Avatar
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    Which one is that? I'm interested and sure people at my work know about it.

    We're also working on CE approval (and FDA in parallel) and it's not easy to get.
    Keep on keepin' the beat alive!

  24. #3804
    Quote Originally Posted by Flixy View Post
    Which one is that? I'm interested and sure people at my work know about it.

    We're also working on CE approval (and FDA in parallel) and it's not easy to get.
    ABSORB is the name of the product; it is made by Abbott. New clinical data just came out in the last few weeks that casts yet more doubt on the efficacy and safety of the stent compared to the newest metal drug-eluting stents.

    CE Mark is not easy to get, but in general the requirements are laxer than for the FDA - the FDA requires bigger, better clinical studies with longer timepoints (typically companies will get approval in Europe first and use data from the European roll-out to get FDA approval). There are exceptions, though, since each class of devices and drugs is regulated differently and there are some faster tracks available at the FDA. The clinical data available when this product got the CE Mark was just ridiculously small sample size and short term follow up. Given that the current gold standard treatment was pretty damned good (this was a non-inferiority design rather than a superiority design) there was no reason to fast-track approval for something so new and with so many serious questions about how it would work in the long term clinically. In this particular case, IMO it borders on negligence.

    The FDA is sometimes to restrictive and cautious, and that is incredibly frustrating (and drives up costs). But we've seen far too many times that their caution is warranted when new classes of therapies come out and end up performing quite poorly.
    "When I meet God, I am going to ask him two questions: Why relativity? And why turbulence? I really believe he will have an answer for the first." - Werner Heisenberg (maybe)

  25. #3805
    Quote Originally Posted by wiggin View Post
    ABSORB is the name of the product; it is made by Abbott. New clinical data just came out in the last few weeks that casts yet more doubt on the efficacy and safety of the stent compared to the newest metal drug-eluting stents.

    CE Mark is not easy to get, but in general the requirements are laxer than for the FDA - the FDA requires bigger, better clinical studies with longer timepoints (typically companies will get approval in Europe first and use data from the European roll-out to get FDA approval). There are exceptions, though, since each class of devices and drugs is regulated differently and there are some faster tracks available at the FDA. The clinical data available when this product got the CE Mark was just ridiculously small sample size and short term follow up. Given that the current gold standard treatment was pretty damned good (this was a non-inferiority design rather than a superiority design) there was no reason to fast-track approval for something so new and with so many serious questions about how it would work in the long term clinically. In this particular case, IMO it borders on negligence.

    The FDA is sometimes to restrictive and cautious, and that is incredibly frustrating (and drives up costs). But we've seen far too many times that their caution is warranted when new classes of therapies come out and end up performing quite poorly.
    Maybe it's because I'm busy getting drunk .....but that sounds just like the 2016 US Presidential election, where people are asking How the Hell did the results stray so far from 'the gold standard' of predictive models? Small sample sizes, bad data, aggregate data, questions about short-term vs long-term effects, unknown effects from fast-tracking, political strategy negligence, etc.

    In the end, I think it boils down to money, and if SICI (that's my acronym for systemically important civic institutions) can compete against SIFI (systemically important financial institutions) for government funding, using tax dollars. Research is important and valuable, but it shouldn't be relegated to "freee market capitalism". The US Space program got us to the moon in the first place.

  26. #3806
    Today I learned that there used to be a primal scream room at our psych clinic. It was used for primal scream therapy but this practice was discontinued a while back. I expect this was because it was constantly occupied by frustrated staff and thus unavailable to patients
    "One day, we shall die. All the other days, we shall live."

  27. #3807
    Hope is the denial of reality

  28. #3808
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    Today I came accross a piece that dealt with a news story I had seen a headline of only hours before. It's that story of the founder of Corona beer leaving his estate to the inhabitants of the village in Spain where he was born. Turns out he did no such thing, despite the 'news' bouncing around over the internet, including on presumably reputable news-sites. The man actually left his estate to his extended family, some of whom lived in said village, part-time. The villagers on the other hand were benefitting from his generosity while he was still alive.

    How fucked up is that?
    Congratulations America

  29. #3809
    Just like that whole fake news bit about CNN showing hardcore porn for a half hour on Thanksgiving night. One person was tweeting about it, not even multiple people, and yet everywhere ran with that stupid story.

  30. #3810

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